Heavy metal is a broad term used to describe a group of naturally occurring metallic elements, such as lead, mercury, and cadmium. Heavy metals are non-biodegradable in nature and may accumulate inside the human body. Most heavy metals are extremely toxic which create various health-related problems. As an example, lead contaminated products from industrial cables and piping can cause heavy metal poisoning. Heavy metal analysis generally involves expensive, complex instrumentation (AA, ICP-MS, ICP-OES), highly trained operators, time intensive sample preparation and comprehensive data interpretation. ANDalyze fluorometer is a handheld instrument that offers quick, accurate, economical and user-friendly heavy metal detection utilizing DNA sensing technology.