AlpHa Measurement Solutions |
Dissolved Oxygen (DO) in Pharmaceutical & Biotechnology
DO in Pharmaceutical & Biotechnology
Dissolved oxygen (DO) can be a critical component or contaminant within different pharmaceutical & biotechnology applications, such as cell growth and fermentation. As a component, DO can be a critical requirement in bioreactors, and when it acts as a contaminant, DO can cause a product to spoil or decrease its shelf life. AlpHa has DO sensor solutions uniquely tailored to each application, including lab electrodes, non-invasive fiberoptic sensors, plastic and needle fiber probes, and single use sensors.
Optical
AlpHa's DO Sensor Capabilities
- Range:
- 0 – 20ppm (0 – 200% saturation)
- 0 – 50ppm (0 – 500% saturation)
- Adjustable within 0 – 50ppm
- Response Time: T90 < ~35 seconds
- Accuracy:
- Dissolved Oxygen
- 0 to 10 mg/L (±1%)
- 10 to 20 mg/L (±2%)
- 20 to 30 mg/L (±5%)
- 30 to 50 mg/L (±15%)
- Temperature: ±0.2°C
- Pressure: ±0.2 kPa
- Dissolved Oxygen
- Temperature Range: 0 to 50°C
- Pressure:
- Operating Atmospheric Pressure: 40 to 115 kPa
- Maximum Bearing Pressure: 700 kPa
- Warranty: 6 to 24 Months Depending on Solution
Fiber and Patch Capabilities
- AP Series
- AP formulation is a highly stable sensor coating with zero drift. Designed for monitoring oxygen partial pressure in gas and dissolved oxygen concentration in liquids for biological environments. AP sensors are compatible with acidic as well as highly caustic environments. Overcoat options exist based on application.
- HCR Series
- HCR is a hydrocarbon-compatible formulation designed to monitor oxygen partial pressure in hydrocarbons such as fuels, organic solvents, oils, and alcohols. Overcoat options exist based on application.
| AP Series | HCR Series | |
| Response Rate | No Overcoat: T90 ~1 sec | No Overcoat: T90 ~1 sec |
| White Overcoat: T90 ~1 min | Black Overcoat: T90 ~1 min | |
| Black Overcoat: T90 ~1 min | ||
| Dynamic Range in Gas | 0 – 100% O2 / 0 – 760 mmHg O2 | 0 – 100% O2 / 0 – 760 mmHg O2 |
| Dynamic Range in Water (DO) | 0 – 40 ppm (wt) | 0 – 40 ppm (wt) |
| Dynamic Range in Other Liquids | 0 to Oxygen Saturation Level | 0 to Oxygen Saturation Level |
| Resolution in Gas | 0.005% O2 / 0.04 mmHg | 0.05% O2 / 0.4 mmHg |
| Resolution in Water (DO) | 0.002 ppm (wt) / 2.0 ppb (wt) | 0.02 ppm (wt) / 20 ppb (wt) |
| Resolution in Other Liquids | 0.005% of Oxygen Saturation Level | 0.05% of Oxygen Saturation Level |
| Accuracy | 5% of Reading | 5% of Reading |
| Lowest Detectable Level (gas) | 0.005% O2 / 0.04 mmHg | 0.05% O2 / 0.4 mmHg |
| Lowest Detectable Level (water) | 0.002 ppm (wt) / 2.0 ppb (wt) | 0.1 ppm (wt) / 100 ppb (wt) |
| Lowest Detectable Level in Other Liquids | 0.005% of Oxygen Saturation Level | 0.25% of Oxygen Saturation Level |
| Sensor Drift | 0.002 O2% per Day | 0.001 O2% per Hour |
| Operating Temperature | -50 to 80°C | -50 to 120°C |
| Recommended Patch Replacement | 1 Year | 1 Year |
Configuration Options
- Optical DO Solutions
- DOPO2 – Fiber Sensor
- Fiber optic sensor for use with remote patches and the electro-optical module
- Optical DO Sensor
- Complete with Integrated Sensor Cap
- Lumiphore Coating on Sensor Cap
- Coating Options Available
- BOD / CBOD Ready Optical DO
- Patches
- AP Series: Water samples, gas samples, and various matrices designed for biological applications
- HCR Series: Hydrocarbon compatible applications (examples such as aviation fuels, gasoline, kerosene, toluene, acetone, UV curable ink, divinylbenzene (DVB), methyl methacrylate (MMA))
- DOPO2 – Fiber Sensor
- Form Factor
- 12 mm
- Process Body
- Plastic Fiber Probe
- Needle Probe
- Dip Probe with Embedded Thermistor
- Sensor Patch
- Non-invasive Patch + Reflective Optical DO
- Cartridge
- Custom Options Available
- Housing Material Options
- Ryton® (PPS)
- Kynar® (PVDF)
- ABS
- Polyethylene
- PEEK
- Semi-Disposable Plastic
- PVC / CPVC
- Metal
- Stainless Steel
- Other Metals Available
- Thermistor Options
- 30 kohm
- Any commercially available thermistors and custom options
- Common temperature accuracy is ±0.3°C and can vary based on thermistor option chosen
- Integrated Insertions
- 3/4" NPT
- 1" NPT
- 1/2" NPT
- BOD Bottle Adapter
- Custom Options Available
Communication and Connection Options
- Analog
- 4 – 20 mA
- 0 – 5 V
- Custom Options Available
- Digital
- RS-485 MODBUS RTU
- Custom Options Available
- Connectors with Cables
- DIN
- Tinned Leads
- SMA (fiber optic probes)
- Circular Connectors
- LEMO
- BNC
- Spade Lugs
- MOLEX
- Mil-spec
- 2.5 mm / 3.5 mm phono
- RCA
- Any commercially available connectors and custom options
Electrochemical
- Range:
- 0 – 20 mg/L (0 – 200% saturation)
- 0 – 50 mg/L (0 – 500% saturation)
- Response Time: T90 < 35 Seconds
- Accuracy: ±2%
- Temperature Range:
- 0 – 50°C Continuously Monitored
- 0 – 80°C Grab Sample
- Warranty: 12 Months
- Technology
- Polarographic
- Platinum Cathode / Silver Anode, Teflon Membrane
- Galvanic
- Platinum Cathode / Lead Anode, Teflon Membrane
- Silver Cathode / Zinc Anode, Teflon Membrane
- Polarographic
- Form Factor
- Process Body
- 12 mm
- Cartridge
- Custom Options Available
- Housing Material Options
- ABS
- Epoxy
- Ryton® (PPS)
- Polycarbonate
- PVC / CPVC
- Custom Options Available
- Thermistor Options
- PT100 (type A & B)
- PT1000
- 10 kohm
- 30 kohm
- 100 kohm
- Any commercially available thermistors and custom options
- Common temperature accuracy is ±0.3°C and can vary based on thermistor option chosen
- Integrated Insertions
- 3/4" NPT
- 1/2" NPT
- 1" NPT
- PG 13.5
- Custom Options Available
- Analog
- Nanoamperes (nA)
- Millivolts (mV)
- Custom Options Available
- Connectors & Cables
- Integrated Connectors (detachable or cableless)
- Variopin
- S7
- S8
- BNC
- Custom Options Available
- Connectors with Cables (including temperature)
- DIN
- Circular Connectors
- LEMO
- Tinned Leads
- Mil-spec
- BNC
- SMA
- Spade Lugs
- MOLEX
- 2.5 mm / 3.5 mm phono
- RCA
- Any commercially available connectors and custom options
- Integrated Connectors (detachable or cableless)